Ocular Pharmacology — Systemic Drug Effects on the Eye

1 / 10

1. Chloroquine/hydroxychloroquine toxicity causes:

1. Corneal guttae

2. Optic nerve pallor only

3. Anterior uveitis

4. Bull's-eye maculopathy (RPE/photoreceptor toxicity)

2 / 10

2. Amiodarone (cardiac antiarrhythmic) causes:

1. Optic neuritis acutely

2. Cataract only

3. Cornea verticillata (whorl-like epithelial deposits)

4. Iris atrophy

3 / 10

3. Topiramate (anticonvulsant) can cause acute bilateral angle closure by:

1. Uveal effusion (supraciliary) causing bilateral angle closure

2. Mydriasis causing pupillary block

3. Corneal edema only

4. Optic nerve swelling

4 / 10

4. Ethambutol (anti-TB drug) causes:

1. Corneal opacity

2. Optic neuropathy with color vision and VF defect

3. Posterior subcapsular cataract

4. Choroidal neovascularization

5 / 10

5. Systemic anticholinergics (e.g., atropine, antihistamines) can precipitate which ocular emergency in susceptible individuals?

1. Optic neuritis

2. Retinal detachment

3. Corneal ulcer

4. Acute angle-closure glaucoma (in narrow-angle eyes)

6 / 10

6. The ocular complication of prolonged use of phenothiazines (e.g., chlorpromazine) is:

1. Optic neuritis only

2. Corneal ulceration

3. Corneal/lens deposits (chlorpromazine) or pigmentary retinopathy (thioridazine)

4. Dry eye only

7 / 10

7. Tamoxifen (breast cancer drug) causes which retinal complication?

1. Crystalline retinopathy with inner retinal deposits and macular edema

2. Optic atrophy only

3. Rubeosis iridis

4. Retinal neovascularization only

8 / 10

8. Rifampicin (anti-TB) can stain which body fluid orange-red, which can stain soft contact lenses?

1. Only urine — irrelevant to eyes

2. Tears orange-red — can permanently stain soft contact lenses

3. Only sweat — no ocular relevance

4. Aqueous humor — visible without slit lamp

9 / 10

9. Systemic corticosteroids used long-term can cause which ocular complication?

1. Posterior subcapsular cataract and steroid-induced glaucoma

2. Optic neuritis only

3. Corneal vascularization

4. Retinal detachment

10 / 10

10. Sildenafil (Viagra) can affect vision by:

1. Transient blue-green color tinge (cyanopsia); risk of NAION in susceptible patients

2. Causing corneal ulceration

3. Causing permanent cataract

4. Elevating IOP acutely

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